Bioadherent oral rinse gel for effective relief of pain associated with oral mucositis
Gelclair is a bioadherent oral rinse gel which provides effective pain relief by adhering to the mucosal surface of the mouth, soothing oral lesions of various etiologies, including oral mucositis/stomatitis (which may be caused by chemotherapy or radiation therapy), irritation due to oral surgery, traumatic ulcers caused by braces or ill-fitting dentures. Gelclair is also indicated for diffuse aphthous ulcers.
- By creating a protective film that counteracts the overstimulation of nerve endings Gelclair provides pain relief 1
- Gelclair improves the ability to eat and drink by reducing pain 2, 4
Gelclair is a concentrated oral rinse gel, classified as a medical device. It contains three main ingredients.
- Polyvinylpyrrolidone (PVP) – A polymer characterized by mucoadhesive and film forming properties that boost the action of sodium hyaluronate.
- Glycyrrhetinic Acid – The breakdown product of the active component of licorice, used as a flavoring agent.
- Hyaluronic Acid (sodium hyaluronate) – A natural polysaccharide with anti-inflammatory and wound healing properties. In the formulation of Gelclair, it acts as a mucoadhesive substance, able to form a film on the mucosal surface.
Gelclair has an optimal pH between 5.5 and 6.5, very similar to the physiological pH of saliva.
- No adverse effects have been reported in clinical trials with the use of Gelclair.
- Postmarketing reports have included infrequent complaints of burning sensation in the mouth.
- There are no known interactions with medicinal or other products.
- Gelclair does not contain alcohol.
- As of 2/2017 no cases of overdose had been reported.
- If Gelclair is swallowed accidently, no adverse effects are anticipated.
- The administration of Gelclair is contraindicated in any patient with a known or suspected hypersensitivity to any of its ingredients.
- Lindsay et al, Australian nursing Journal April 2009(16); 9: 30-33.
- D’Andrea et al, Annals Oncol 2003; 14(supp4): 97(abstract N2).
- De Cordi D et al, Conegliano, October 10-12, 2001.